HSEGHMM: HIDDEN MARKOV MODEL-BASED ALLELE-SPECIFIC COPY NUMBER ALTERATION ANALYSIS ACCOUNTING FOR HYPERSEGMENTATION

hsegHMM: hidden Markov model-based allele-specific copy number alteration analysis accounting for hypersegmentation

Abstract Background Somatic copy number alternation (SCNA) is a common feature of the cancer genome and is associated with cancer etiology and prognosis.The allele-specific SCNA analysis of a tumor sample aims to identify the allele-specific copy numbers of both alleles, adjusting for the ploidy and Mug the tumor purity.Next generation sequencing p

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Fixed bin frequency distribution for the VNTR Loci D2S44, D4S139, D5S110, and D8S358 in a population sample from Minas Gerais, Brazil

Fixed bin frequencies for the VNTR loci D2S44, D4S139, D5S110, and D8S358 were determined in a Minas Gerais B1 Vitamins / Thiamine population sample.The data were generated by RFLP analysis of HaeIII-digested genomic DNA and chemiluminescent detection.The four VNTR loci have met Hardy-Weinberg equilibrium, and there was no association of alleles am

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